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Lisinopril and oral lichen planus inhibitor drugs. The other study, also published in the Journal of American College Cardiology, found that a high dose of rofecoxib, newly approved antidepressant, may reduce your risk of death by up to 40 percent. The investigators analyzed data on 13,961 people, who were between the ages of 45 and 94 at the time of study, who took at least one of two different types antidepressants and were also at risk of heart failure and stroke. The study, which is being funded by GSK, conducted at 30 hospitals around the United States. Researchers found an increased risk in people who had taken rofecoxib with an ACE inhibitor before they were given those drugs. But the risk remained same if no medications were given with acetylsalicylic acid (ASA) or an ACE inhibitor prior to taking rofecoxib. "We do recommend clinicians evaluate the risks of taking an ACE inhibitor and a SSRI (selective serotonin reuptake inhibitor) before prescribing any combination of antidepressant medications," the authors wrote. The results are in line with data from an earlier study led by the same group of researchers, who reported that in a similar group of more than 200,000 people who had strokes, those took a high-dose of ASA or an ACE inhibitor and a high-dose of rofecoxib had up to a 40 percent lower risk of death. There was no similar study for rofecoxib and ASA or an ACE inhibitor. A previous European trial had found that rofecoxib was also associated with a lower risk of death in people with type 2 diabetes but the new report raises possibility that the two medications may act independently lisinopril oral price or in combination to reduce the risk associated with strokes or heart failure. "This study adds to this evidence and discussion of rofecoxib, suggests that if you have a history of heart failure or stroke [the combination] may be worth trying," says Dr. Joseph V. Hagan, chair of the department psychiatry and pediatrics director of the Vanderbilt Center for Research in Depression, who was not involved with the study. A similar study in people with high blood pressure also reported that ASA and an ACE inhibitor reduced the risk of dying. researchers estimated that the death rate for people taking ASA plus an ACE inhibitor was between 13 percent and 15 lower than for people taking ASA alone, generic viagra canada online pharmacy and that those taking rofecoxib ASA had a rate of death about twice those people taking either drug, regardless of which drug they took. But it is unclear why the high-dose ASA and ACE inhibitor combination was associated with lower mortality, as it was with strokes. The researchers did not observe an increased risk of strokes associated with taking rofecoxib alone. People the same medication with ASA and an ACE inhibitor had a 20 percent lower risk of stroke than those taking ASA alone. Similarly, people rofecoxib followed by an ASA and ACE inhibitor had an 8 percent lower risk of stroke than people taking both medicine together. "We don't think that rofecoxib is a stroke drug. They both may have a role in stroke prevention," Hagan says. It may be possible to take either medication or combination drugs -- either of ASA and ACE inhibitor either high-dose ASA plus ACE inhibitor or alone -- and see fewer side.

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